Experimental spiritualism as a fringe science played a significant role in Europe’s intellectual life in the late 19th century. Its adherents considered questions of science and religion crucial for developing the right methods of scientific research. This article consists of four parts: (1) theoretical, which provides an overview of subject-object relations in the current theory of classical/non-classical epistemology; (2) historical, which investigates the opposition of “science” and “religion” as different spheres of modern human experience, and proposes a “reality principle” as the main principle of both classical epistemology and theology; (3) typological, which presents a typology of different epistemological models in Russian spiritualism based on the archival materials of its main adherents; (4) analytical, which deals with experimental spiritualism as fringe science that emerged during a paradigm shift from classical to non-classical science.